| 151* | CH Gayle | Somerset v Kent | 2015 | tt4938 |
| 129* | JM Vince | Hampshire v Somerset | 2022 | tt11020 |
| 116* | IJ Thomas | Glamorgan v Somerset | 2004 | tt78 |
| 116* | CL White | Somerset v Gloucestershire | 2006 | tt368 |
| 114 | SA Northeast | Kent v Somerset | 2015 | tt4938 |
| 107 | ME Trescothick | Somerset v Worcestershire | 2008 | tt966 |
| 107* | JC Hildreth | Somerset v Glamorgan | 2012 | tt2995 |
| 105 | GC Smith | Somerset v Northamptonshire | 2005 | tt216 |
| 103* | JG Myburgh | Somerset v Essex | 2018 | tt7091 |
| 101 | M Klinger | Gloucestershire v Somerset | 2016 | tt5790 |
| 101* | TB Abell | Somerset v Middlesex | 2019 | tt8112 |
| 100 | T Banton | Somerset v Kent | 2019 | tt8048 |
| 100 | DJ Bell-Drummond | Kent v Somerset | 2025 | tt15288 |