| 1 | 162 | MJ Guptill & JM Clarke | Worcestershire v Northamptonshire | 2018 | tt7066 |
| 2 | 150 | A Lyth & DJ Willey | Yorkshire v Northamptonshire | 2018 | tt7144 |
| 3 | 102 | MH Wessels & SR Patel | Nottinghamshire v Northamptonshire | 2014 | tt4463 |
| 4 | 146 | SJ Croft & DJ Mitchell | Lancashire v Northamptonshire | 2023 | tt12348 |
| 5 | 100* | AJ Hose & CG Benjamin | Warwickshire v Northamptonshire | 2022 | tt11016 |
| 6 | 91 | DJ Vilas & R McLaren | Lancashire v Northamptonshire | 2017 | tt6381 |
| 7 | 67 | OAC Banks & BJ Phillips | Somerset v Northamptonshire | 2008 | tt985 |
| 8 | 58 | TAI Taylor & AJ Tye | Northamptonshire v Lancashire | 2023 | tt12348 |
| 9 | 46* | RE van der Merwe & ORT Sale | Somerset v Northamptonshire | 2020 | tt8905 |
| 10 | 33 | NL Buck & BW Sanderson | Northamptonshire v Warwickshire | 2021 | tt9675 |