| 136 | JM Clarke | Nottinghamshire v Northamptonshire | 2021 | tt9659 |
| 113* | DT Christian | Nottinghamshire v Northamptonshire | 2018 | tt7017 |
| 113* | CA Lynn | Northamptonshire v Worcestershire | 2022 | tt10941 |
| 110* | CA Lynn | Northamptonshire v Leicestershire | 2023 | tt12273 |
| 106* | CA Lynn | Northamptonshire v Leicestershire | 2022 | tt10882 |
| 104 | CS MacLeod | Derbyshire v Northamptonshire | 2018 | tt7052 |
| 103 | JJ Cobb | Northamptonshire v Warwickshire | 2018 | tt7100 |
| 103* | JP Inglis | Leicestershire v Northamptonshire | 2021 | tt9718 |
| 102 | MJ Guptill | Worcestershire v Northamptonshire | 2018 | tt7066 |
| 102* | G Clark | Durham v Northamptonshire | 2023 | tt12202 |
| 101* | HH Gibbs | Yorkshire v Northamptonshire | 2010 | tt1821 |
| 101 | SJ Croft | Lancashire v Northamptonshire | 2023 | tt12348 |