| 244 | PP Shaw | Northamptonshire v Somerset | 2023 | a30124 |
| 185* | DJ Malan | England Lions v Sri Lanka A | 2016 | a24824 |
| 161 | DJG Sales | Northamptonshire v Yorkshire | 2006 | a17437 |
| 153* | RJ Bailey | Northamptonshire v Pakistan A | 1997 | a10661 |
| 152* | GS Ballance | Yorkshire v Northamptonshire | 2017 | a25563 |
| 151 | C Munro | New Zealand A v Northamptonshire | 2014 | a23445 |
| 151 | C de Grandhomme | New Zealand A v Northamptonshire | 2014 | a23445 |