| 244 | PP Shaw | Northamptonshire v Somerset | 2023 | a30123 |
| 185* | DJ Malan | England Lions v Sri Lanka A | 2016 | a24823 |
| 161 | DJG Sales | Northamptonshire v Yorkshire | 2006 | a17436 |
| 153* | RJ Bailey | Northamptonshire v Pakistan A | 1997 | a10660 |
| 152* | GS Ballance | Yorkshire v Northamptonshire | 2017 | a25562 |
| 151 | C Munro | New Zealand A v Northamptonshire | 2014 | a23444 |
| 151 | C de Grandhomme | New Zealand A v Northamptonshire | 2014 | a23444 |