| 162 | CH Gayle | West Indies v England | 2018/19 | o4099 |
| 150 | JC Buttler | England v West Indies | 2018/19 | o4099 |
| 146 | AB de Villiers | South Africa v West Indies | 2006/07 | o2567 |
| 130 | J Charles | West Indies v Zimbabwe | 2012/13 | o3337 |
| 126 | SR Watson | Australia v West Indies | 2008 | o2724 |
| 125* | WW Hinds | West Indies v Australia | 2002/03 | o2020 |
| 120* | RR Sarwan | West Indies v Zimbabwe | 2012/13 | o3339 |
| 111* | SB Styris | New Zealand v Sri Lanka | 2006/07 | o2569 |
| 110* | DS Lehmann | Australia v West Indies | 1998/99 | o1436 |
| 109 | Anamul Haque | Bangladesh v West Indies | 2014 | o3509 |
| 107 | JH Kallis | South Africa v West Indies | 2000/01 | o1714 |
| 107 | DS Lehmann | Australia v West Indies | 2002/03 | o2021 |
| 105* | Imran Nazir | Pakistan v Zimbabwe | 1999/00 | o1590 |
| 103* | WW Hinds | West Indies v Australia | 2002/03 | o2021 |
| 103 | ML Hayden | Australia v New Zealand | 2006/07 | o2577 |
| 103 | EJG Morgan | England v West Indies | 2018/19 | o4099 |
| 102 | E Lewis | West Indies v Ireland | 2019/20 | o4230 |
| 100* | DM Bravo | West Indies v Zimbabwe | 2012/13 | o3337 |