| 162 | CH Gayle | West Indies v England | 2018/19 | a27039 |
| 150 | JC Buttler | England v West Indies | 2018/19 | a27039 |
| 146 | AB de Villiers | South Africa v West Indies | 2006/07 | a18177 |
| 130 | J Charles | West Indies v Zimbabwe | 2012/13 | a22453 |
| 126 | SR Watson | Australia v West Indies | 2008 | a19054 |
| 125* | WW Hinds | West Indies v Australia | 2002/03 | a15142 |
| 120* | RR Sarwan | West Indies v Zimbabwe | 2012/13 | a22457 |
| 111* | SB Styris | New Zealand v Sri Lanka | 2006/07 | a18179 |
| 110* | DS Lehmann | Australia v West Indies | 1998/99 | a11851 |
| 109 | Anamul Haque | Bangladesh v West Indies | 2014 | a23504 |
| 107 | JH Kallis | South Africa v West Indies | 2000/01 | a13450 |
| 107 | DS Lehmann | Australia v West Indies | 2002/03 | a15145 |
| 106 | LMP Simmons | West Indies A v Sri Lanka A | 2013 | a22706 |
| 105* | Imran Nazir | Pakistan v Zimbabwe | 1999/00 | a12654 |
| 103* | WW Hinds | West Indies v Australia | 2002/03 | a15145 |
| 103 | ML Hayden | Australia v New Zealand | 2006/07 | a18187 |
| 103 | EJG Morgan | England v West Indies | 2018/19 | a27039 |
| 102 | E Lewis | West Indies v Ireland | 2019/20 | a27929 |
| 100* | DM Bravo | West Indies v Zimbabwe | 2012/13 | a22453 |