| 153 | HH Gibbs | South Africa v Bangladesh | 2002/03 | o1890 |
| 147* | MV Boucher | South Africa v Zimbabwe | 2006/07 | o2420 |
| 119* | H Klaasen | South Africa v West Indies | 2022/23 | o4543 |
| 116 | GC Smith | South Africa v New Zealand | 2012/13 | o3328 |
| 110 | HM Amla | South Africa v Zimbabwe | 2010/11 | o3059 |
| 108 | M Labuschagne | Australia v South Africa | 2019/20 | o4254 |
| 106* | RN ten Doeschate | Netherlands v Kenya | 2008/09 | o2831 |
| 105* | N Boje | South Africa v New Zealand | 2000/01 | o1641 |
| 103* | MJ Guptill | New Zealand v South Africa | 2015 | o3677 |
| 102* | DL Hemp | Bermuda v Kenya | 2008/09 | o2835 |
| 102* | AK Markram | South Africa v Australia | 2023/24 | o4642 |
| 101* | AB de Villiers | South Africa v Zimbabwe | 2010/11 | o3059 |