| 121 | JT Smuts | Warriors v Lions | 2018/19 | tt7898 |
| 120* | NT Tilak Varma | India v South Africa | 2024/25 | tt14358 |
| 119 | F du Plessis | South Africa v West Indies | 2014/15 | tt4689 |
| 117 | CH Gayle | West Indies v South Africa | 2007/08 | tt713 |
| 113* | F du Plessis | Joburg Super Kings v Durban's Super Giants | 2022/23 | tt11932 |
| 109* | SV Samson | India v South Africa | 2024/25 | tt14358 |
| 104* | RR Hendricks | Jozi Stars v Durban Heat | 2018/19 | tt7307 |
| 104 | T Bavuma | Lions v Warriors | 2018/19 | tt7898 |
| 104 | HE van der Dussen | MI Cape Town v Joburg Super Kings | 2023/24 | tt13084 |
| 102* | MY Cook | Gauteng v Border | 2014/15 | tt4646 |
| 100 | SA Yadav | India v South Africa | 2023/24 | tt13005 |