| 122 | Babar Azam | Pakistan v South Africa | 2020/21 | tt9537 |
| 118 | J Charles | West Indies v South Africa | 2022/23 | tt12075 |
| 117 | RR Hendricks | South Africa v Pakistan | 2024/25 | tt14611 |
| 116* | K Verreynne | Pretoria Capitals v MI Cape Town | 2023/24 | tt13171 |
| 114* | MK Pandey | Royal Challengers Bangalore v Deccan Chargers | 2009 | tt1205 |
| 108 | Q de Kock | Cape Town Blitz v Tshwane Spartans | 2018/19 | tt7308 |
| 107* | NT Tilak Varma | India v South Africa | 2024/25 | tt14353 |
| 104* | H Klaasen | Durban's Super Giants v Pretoria Capitals | 2022/23 | tt11965 |
| 103* | SJ Erwee | Dolphins v Cape Cobras | 2017/18 | tt6545 |
| 102* | BR Parsons | KwaZulu-Natal Coastal v Northerns | 2023/24 | tt13394 |
| 101 | WG Jacks | Pretoria Capitals v Durban's Super Giants | 2023/24 | tt13104 |
| 100 | AK Markram | Sunrisers Eastern Cape v Joburg Super Kings | 2022/23 | tt11975 |
| 100 | Q de Kock | South Africa v West Indies | 2022/23 | tt12075 |