| 6 | JH Kallis | Sri Lanka v South Africa | 2011/12 | t2028 |
| 6 | SPD Smith | South Africa v Australia | 2017/18 | t2300 |
| 6 | BA Stokes | South Africa v England | 2019/20 | t2379 |
| 6 | DG Bedingham | Pakistan v South Africa | 2024/25 | t2576 |
| 5 | GA Faulkner | England v South Africa | 1909/10 | t109 |
| 5 | AB de Villiers | Australia v South Africa | 2017/18 | t2300 |