| 160 | JH Kallis | South Africa v New Zealand | 2000/01 | t1514 |
| 157 | GC Smith | South Africa v Bangladesh | 2008/09 | t1893 |
| 155 | SR Tendulkar | India v South Africa | 2001/02 | t1564 |
| 143 | AK Markram | South Africa v Bangladesh | 2017/18 | t2278 |
| 135* | F du Plessis | South Africa v Bangladesh | 2017/18 | t2278 |
| 132 | HM Amla | South Africa v Bangladesh | 2017/18 | t2278 |
| 113 | D Elgar | South Africa v Bangladesh | 2017/18 | t2278 |
| 112 | HM Amla | South Africa v Bangladesh | 2008/09 | t1893 |
| 108 | L Klusener | South Africa v India | 2001/02 | t1564 |
| 107 | HH Gibbs | South Africa v India | 2001/02 | t1564 |
| 105 | V Sehwag | India v South Africa | 2001/02 | t1564 |