| 6-24 | Imran Tahir | South Africa v Zimbabwe | 2018/19 | o4050 |
| 6-58 | LT Ngidi | South Africa v Australia | 2019/20 | o4252 |
| 5-42 | L Klusener | South Africa v India | 1996/97 | o1167 |
| 4-19 | J Botha | South Africa v Kenya | 2008/09 | o2769 |
| 4-22 | RK Kleinveldt | South Africa v Pakistan | 2012/13 | o3343 |
| 4-24 | M Ntini | South Africa v Bangladesh | 2002/03 | o1962 |
| 4-27 | AB Agarkar | India v Kenya | 2001/02 | o1758 |
| 4-29 | D Gough | England v South Africa | 1999/00 | o1546 |
| 4-42 | JF Kloppenburg | Netherlands v Namibia | 2002/03 | o1978 |
| 4-42 | Adeel Raja | Netherlands v Namibia | 2002/03 | o1978 |
| 4-44 | KLT Arthurton | West Indies v South Africa | 1998/99 | o1402 |
| 4-48 | A Zampa | Australia v South Africa | 2023/24 | o4638 |
| 4-61 | T Shamsi | South Africa v Australia | 2023/24 | o4638 |
| 4-62 | AA Nortje | South Africa v England | 2022/23 | o4512 |
| 4-63 | B Lee | Australia v South Africa | 2001/02 | o1822 |
| 4-86 | SW Masakadza | Zimbabwe v South Africa | 2010/11 | o3057 |