| 317 | HC Brook | England v Pakistan | 2024/25 | t2553 |
| 309 | V Sehwag | India v Pakistan | 2003/04 | t1693 |
| 262 | JE Root | England v Pakistan | 2024/25 | t2553 |
| 216 | BC Lara | West Indies v Pakistan | 2006/07 | t1816 |
| 194* | SR Tendulkar | India v Pakistan | 2003/04 | t1693 |
| 193 | ME Trescothick | England v Pakistan | 2005/06 | t1770 |
| 191 | Mohammad Yousuf | Pakistan v West Indies | 2006/07 | t1816 |
| 151 | Shan Masood | Pakistan v England | 2024/25 | t2553 |
| 138* | Inzamam-ul-Haq | Pakistan v Bangladesh | 2003/04 | t1658 |
| 122 | Salman Butt | Pakistan v England | 2005/06 | t1770 |
| 118 | Kamran Ghulam | Pakistan v England | 2024/25 | t2554 |
| 114 | BM Duckett | England v Pakistan | 2024/25 | t2554 |
| 112 | Mohammad Yousuf | Pakistan v India | 2003/04 | t1693 |
| 110* | Abdul Razzaq | Pakistan v Bangladesh | 2001/02 | t1560 |
| 108 | HC Brook | England v Pakistan | 2022/23 | t2480 |
| 105* | Inzamam-ul-Haq | Pakistan v Bangladesh | 2001/02 | t1560 |
| 104 | Taufeeq Umar | Pakistan v Bangladesh | 2001/02 | t1560 |
| 104* | Agha Salman | Pakistan v England | 2024/25 | t2553 |
| 102* | Mohammad Yousuf | Pakistan v Bangladesh | 2001/02 | t1560 |
| 102 | Abdullah Shafiq | Pakistan v England | 2024/25 | t2553 |
| 101 | Saeed Anwar | Pakistan v Bangladesh | 2001/02 | t1560 |